Showing posts with label bipolar. Show all posts
Showing posts with label bipolar. Show all posts

Sunday, December 2, 2012

Post Traumatic Stress Disorder: Psychiatric comorbidity and complications, Athens Psychiatric Conference, Dec. 2, 2012

These are my rough notes from this lecture which was very impressive indeed with an excellent case presentation that led to much audience participation.

 Post Traumatic Stress Disorder: Psychiatric Comorbidity and Complicatios The First Interdisciplinary Congress "Psychiatry and Related Sciences" Chairs: I Reznick (Israel) , D. Papadatou (Greece) 

Psychiatric Comordity in PTSD Alevizopoulos (Greece)

 PTSD - 80% have co morbidity - -axis I - depression, substance abuse axis 2 - Borderline Personality Disorder Trauma doesn’t necessarily lead to ptsd

Case:  PTSD, Borderline , Substance abuse and mood disorder nexus -Oedipus suffered physical abuse and abandonment -adopted -developed substance abuse in adolescent -cruelly killed 5 strangers in minor road incident- impulsivity/borderline/mani -when crimes solved - attempted suicide - manipulative/borderline

Question and Answer Borderline personality disorders and Bipolars are similiar in ways Personality develops and trauma makes difference - don’t think ptsd leads to borderline or antisocial but can be anticedents - described production of cortisol as a factor in develpment after trauma
Discussion of sexual abuse and truama versus war trauma differentiate brother sister versus mother son and subsequent development of psychopathology
Discussion of PTSD incidence based on different countries experience Papadatou - offered that research on the ‘subjective experience’ of the trauma significant to development of trauma
Resilence offered as a consideration

I found this presenter to be incredibly experienced, informative, articulate, and at times amusing in that kindly way only a true clinician can be. Thoroughly delightful. DSCN0252 DSCN0253 DSCN0255

Wednesday, March 21, 2012

Therapies for Depression

Depression is a broad term to describe a psychiatric state of literally, unhappiness.  So called Clinical Depression refers to some such state that persists for at least a couple of weeks. It's associated with a depressed mood, most of day, most every day.  Sleep and motivation and cognitive function can all be affected.  There have been a wide variety of terms over the year to describe this state.  It's been called dysthymia, major affective disorder, mood disorder, major mood disorder, and at it's most extreme melancholia.  It's differentiated from the blahs by being a bit more severe and lasting a bit longer. It's differentiated from Grief or Bereavement, the natural state of loss when a loved one is lost, by lasting much longer.
At the turn of the century a study in Pennsylvania at a farm when Quakers kept people who came with mental illness treating them with tender loving care but not much else, the length of 'untreated major depression' was approximately 9 months.  Adjustment disorders, a reaction to a negative event in one's life such as the loss of a job or the break up of a dating realationship was considered to be about 6 months. The depth of suffering with an adjustment disorder could be as great as major mood disorder but if the disorder laster longer or was greater then the term major mood disorder or major affective disorder was used to describe the experience.  There have been some who wrongly defined adjustment disorders as 'minor' depressions but adjustment referred to the presence of an identifiable stressor. In Major Mood Disorder alone a person might have a stressor or not.
Indeed there is a tendency in the pharmacological industry associated psychiatric diagnosis to described disorders independent of the causation. Hence the 'antidepressants' medication is likened to 'fever' medication, like Aspirin and Acetomenophen.  People can have pain for a variety of reasons but aspirin or tylenol tend to treat the 'pain' regardless. There's this kind of non specific benefit noted with the antidepressant medications so that in association the term "major mood disorder' has by convention been likened to the condition a psychiatrist would use an antidepressant with.
That said depression and moods in general can be altered by a variety of factors in terms of the individual, their relationship or environment.  A large number of physical medica conditions give rise to depression. Often the first presentation of an underlying major medical physical illness is depression. Cancer, Diabetes, Heart Disease, Chronic low grade infections, Anemia, Metabolic Diseases, all commonly present with depression as the first sympton of the disorder.  For this reason people with persisting depression often benefit from seeing their family doctor who can readily rule out the major and more likely conditions that may present as depression.
Many of my patients have come to me after months of psychological treatments or counselling when they had an undiagnosed physical disease which was causing the person to have low mood, loss of energy and sleep problems and cognitive difficulties. The diagnosis of depression was correct. It's just that the cause and treatment had been wrong.  I saw one poor gentleman after a year of weekly psychotherapy and all manner of discussion of his sex life when he had an anemic condition. When the anemia was treated his mood improved and he no longer had need for psychological treatment and certainly was disheartened by the year of therapy, the $10,000 of dollars cost and the loss of work and relationship which had occurred. In several cases depression was the way my patients breast cancer presented. I did an appropriate medical screening history and found that they had other symptons of concern.  Hundreds of cases that have come to me for depression, even those who have seen family physicians before me have turned out to have a physical illness which when treated caused the patient to no longer need antidepressants or depression therapy.
The message there is 'screening'.  Give a boy a hammer and everything is a nail. That's the problem with counsellors.  They over diagnosis psychological depression and miss the other often common causes.
Psychosocial reasons for depression abound.  Often people become depressed by lack of exercise.  Scientific studies have shown that 1 half hour of aerobic exercise daily has the equivalent benefit on mood as taking prozac 10 mg daily has.
Often people who have eating disorders are depressed. Both obesity and anorexia are associated with depression.
All the addictions are associated with depressions.  Alcohol is a 'depressive'.  Cocaine is a 'stimulant' but it quickly depletes the bodies stimulant neurotransmitters and causes a depression as a result.  Addictions are generally associated with a dramatic high followed by a low. Sex addicts get this and eventually the flogging of the dead horse phenomena in addiction leads to chronic depression and dysthymia.  Bipolar II in the diagnosis associated with addiction until proven otherwise.
Chronic anxiety states lead to depression. Indeed the Seligman 'learned helplessness' studies suggest that depression is a chronic anxiety state.  There's work with neuro implants that suggest that chronic anxiety may set up a derailed neurotransmitter pathway that requires a 'brain pacemaker' to disrupt and restore a person to having normal neurotransmitter release.
Electroshock therapy served to 'reset' this distrurbed neurotransmitter system.  Serotonin deficiency was disagnosed in the cerebral spinal fluid of suicidals and the general pharmacalogical explanation for depression was a low serotonin or noradrenaline state.  It's now recognised that there's more likely an imbalance between varying neuro pathways serving to maintain equilibrium.
All manner of therapies have therefore been scientifically shown to be beneficial in the treatment depression.  Prevalence studies of depression show as much as 30% of a population base may have some form of depression at any time.
Talking therapies - counselling - psychotherapy -have all been shown to be beneficall. The is much competition between the various 'schools' of thought and the 'latest' brand of therapy but one very interesting study some years ago showed that psychiatrists with 10 years of clinical therapy experience regardless of their theoretical basis had the same general benefit.
The 'convention' is to use a 'cognitive behavioural therapy' today, mostly because it's so easy to train a person in and therefore costs less. Psychodynamic therapies have equal if not greater success in the treatment of depressive disorders but require more training and are more difficult to learn than 'cognitive behavioural therapy'.
Generally speaking 'relationship therapies' have been good with most depressions.  Garden variety depressions were what we always gave the new residents as they tended to respond to any form of positive hopeful encounter.
Having branched out in to other areas of study I've seen that "pastoral counselling' has been effectively treating depression quietly for centuries because it combines cognitive behavioural therapies idea, with relationship therapy and even has the 'lending the ego' elements which were beneficial in psychoanalytic therapies.
The advantage of psychotherapies over doing nothing was the generally speaking it's been shown that therapy shortens the length of the dysfunction associated with depression and the risk of suicide.  Considering untreated depression can last 9 months, most counselling therapies result in a depressive episode getting better in 6 to 10 weeks.
Indeed prozac the antidepressant was considered a success because it was shown to have relatively equivalent benefit to 10 weeks of psychotherapy.  Combined psychotherapy and psychopharmacology, the person improved symptomatically but the potential for recurrence was also reduced.
Individual therapy is expensive as any labour intensive therapy is. Therefore there have been studies on group therapy especially with cognitive behaviour therapy which really lends itself to the class room. Indeed I  might argue that individual therapy of the CBT nature should only be considered when group therapy had failed.
Misery loves company. A significant success of the self help movement has been it's ability to counteract the tendency to isolation.
Spiritual people as evidenced by a measurable variable such as church attendance have less likelihood of depression and respond to treatment better with greater success.
Seligman at his Authentic Happiness site has been doing research on improving the various traits that counteract depression, two specifically being hope and reslience.
While a lot of people think that depression should be a reason to not be working, not working can actually make depression worse. Clearly a pilot who has depression may present a risk for his passengers but if he is sent home 'to rest' , the isolation might indeed make the depression worse. A very effective therapeutic strategy employed by the British Columbia worksafe program was to have depressed patients attend a daily coffee house thereby ensuring that they had the occupation benefits associated with group therapy and socialization.  People who isolate worsen their depression.
However depressives can run in 'packs'. Individually I've treated dozens of patients by encouraging them to reduce the contact with 'sick' people in their social network. It's the 'dosage' of the relationship that is sickening. One women became physically ill if she talked to her deeply mentally ill mother for more than a half hour a week. The mother was dependent and clinging and literallly what caloquially we'd call a soul sucker. In contrast one of my male patients had only to talk to his father for an hour and his father was constantly demeaning to him causing him to be literally suicidal.  Again by limitting the dose of the relationship to 15 minute contacts the man was able to get better. I routinely ask depressed patients to avoid the news in whatever form since it's commonly old and depressing.
Music therapy has been shown to be a treatment for depression. It's especially beneificall if people are themselves participating in making the music.
Given the wide range of successful treatments available it's usually beneficial to consider the efficiency and cost effectiveness of a therapy.
Magnetic therapies have been shown to be very effective for therapy and equivalent in some patients as medication therapy however right now the cost is higher than electroconvulsive therapies.
Hypno therapy is an effective therapy for depression as is neurotherapy.
Often the therapy that is used is the one most available in the community.  It's also is affected by what experience the therapists have. In eastern Canada it's common that there are a psychotherapeutically trained psychiatrist with extensive experience in a variety of non pharmacological treatments as well as pharmacalogical treatments and physical treatments. In western canada it's most common that the psychiatrists are only trained in psychopharmacology or if trained in other forms of therapy these are supported by the community financially or professionally.
Massage therapy is very attractive to patients. I once asked my heroin addicts if they had the choice of going to detox or massage therapy which would they choose.  They'd naturally choose massage therapy.  Unfortunately there's no evidence that massage therapy is an effective treatment for heroin addiction.  Abstinence is and detox is not nearly as pleasant as doing heroin and getting a government funded massage.
No one ever questions what individuals do to treat their own depressions. This is in fact the 'right' to 'pursuit of happiness'.  I personally find riding my Harley Davidson Electraglide an antidepressant but it's most unfortunate I can't convince an insurance body to pay for my motorcycle. Similiarly i personly think that if I were depressed I'd benefit from a year of high paid tropical therapy on a beach. I suspect I could devise a scientific study to show that this did work but the cost would be prohibitive for any insurance company.
Much of the failure in treatment of depression has been due to the failure of patients to follow medical regimens, such simple suggestions as don't drink alcohol or exercise a half hour a day, or get out of bed.
Dance therapy is an effective therapy for depression.  I used dance and psychodrama to effectively treat depressed patients. There's just no support in the very conservative medical system for me to do these therapies. I'd need a larger office or space where I could do dance. I have a group therapy that helps depression but even to have a group therapy in my office I have to pay the higher overhead costs for the office that can hold 10 people at a time.  Further the medical service plan discourages me from having group therapy because it's more time and effort for my staff to arrange and bill and yet there's no commiserate increase in the therapy cost.
So there's lots of therapies and lots work. The choice of therapy and indeed the choices available are numerous. People don't need to be depressed. Talk about it and get help.
When I started in psychiatry I commonly talked with patients and rather quickly they got better. Often just listening to people who had otherwise well established lives served to result in their mood improving.  Later I would see more complex problems with less and less resources and more and more demands on my services.  As a result I tended to use medications more often. Commonly I have the pleasure and benefit of working with a psychologist or occupational therapist who does the lions share of talk therapy.  I'm a consultant and diagnostician and the the psychopharmacologist in these arrangements.  The psychologists and counsellors and occupation therapists can't prescribe medications and aren't aware of the whole medical and neurological aspects of depression which can be an important part.  A number of the psychologists I work with a specifically trained in a subset of patients and their experience and training makes them especially good with this group of patients. My experience and training is really broad based with some subspecialty areas so it's refreshing to work with psychologists who are subspecialists themselves. Increasingly family physicians are working psychologically with patients so that makes things easier all round.
I still come across alot of depressed negative people in my daily walk in life.  It's like the number of addicts who actually access treatment. Very few. So commonly I'm treating an addict in the office but there are a dozen or so more who deny they have addiction and attribute their regular social and occupational problems to the 'other guy'.  Similiarly depressive people often are the last to seek help which is unfortunate too.
When I consider psychiatric illness I often think it was akin to physical illness in the 30's. All manner of people had physical illness like heart disease or treatable infections or cancers but they never sought help for them. As a result the morbidity and mortality rate only one or two generations ago was so much higher.  Today people have much more 'quantity' of life in general but the 'quality 'is still an issue.
Ironically alot of people think that they'd be happy if they were rich but wealth is not a cure for depression and not a guarantee against it.  I used to think if I lived on a tropical island I d not see depression becuase I'd associated it more with the dreary winter months but when I worked on a tropical island I saw just as much depression.  I have been thankful for the wide range of therapies that I've learned, the excellent psychopharmacologies and elegant psychotherapies.


Thursday, November 24, 2011

Marijuana and Mental Health Controversy

The controversy surrounding marijuana as medicine has changed dramatically in the last 20 years.  20 years ago it was clearly 'illegal' and as such using it was evidence of 'addiction' as the risk/benefit ratio was so negatively weighted with potential incarceration and long  term negative consequences of criminal record.
These days the 'value' of marijauana continues to be supported especially with newer pharmaceutical cannabinoids seeking approval every month.  Further the federal Canadian political legislation has essentially 'decriminalized' marijuana by making it a 'medicine'.  Even in California someone wanting to smoke marijuana just needs to create a disease category, present with symptons and go to the drive through marijuana clinics making millions with the new laxity of the laws there.
There is still no support for 'smoke' of any kind.
But there's really good evidence for it's benefit in spasms and chronic pain especially 'neuropathic' pain (nerve pain) and also with nausea.  The benefits of the pharmaceutical components of standard marijuana are clearly outweighed by 'smoking', marijauna's dangers being essentially the same as tobacco smokers with chronic respiratory disease, cancer, asthma and heart disease associated with smoking. Smoking isn't good for you.
So marijuana cookies and tea are probably okay especially for Multiple Sclerosis and Nerve root pain in Diabetics. It was once the drug of choice for nausea in cancer treatment but better drugs have been developed.  The trouble is marijuana 'users' want to 'smoke' it suggesting that the majority of such are using it not for intrinsic slow release 'medical value' but it's ability to cause a 'high'.  Smoked marijuana is decidedly the route of choice for addicts.
Cesamet, Nabilone and Sativex are pharmaceutical cannabinoids.  Cesamet is on the provincial formulary for chronic pain.
The difficulty though is that 'smoking' is an 'addictive' 'process'.  This was seen with people given nicotine patches who smoked on top of that.  It's the 'ritual'.  Heroin addicts will 'shoot up' rather than 'smoke' heroin once they become addicted to the paraphernalia. There is a link between addiction and rapid access to brain of the compound.
But here's the controversy in mental health.  The Diagnostic and Statistical Manual of the American Psychiatric Association describe clearly Cannibis (Marijuana) Induced Anxiety Disorder and Cannibis (Marijuana) Induced Psychosis.  Bipolar II , the bipolar disorder associated with angry mood swings as opposed to Bipolar I where the mood swings are euphoria and depression, is the most common mood disorder in combination with addiction, clinically.  It's no stretch to say that Cannibis Induced Mood Disorder is readily apparent too.
So how do you decided if the Anxiety Disorder is a product of marijuana use or helped by marijuana use. The subjective experience of alcoholics is that alcohol makes them calmer and less violent yet the overwhelming community experience and 'objective' experience is that this is simply not the case. There is indeed a benefit from one drink and even an alcoholic will be calmed initially by one drink as a marijuana smoker will describe a joint benefiting their anxiety for a half an hour. The anxiety that follows is worse though and with addiction there is increasing need for more substance with decreasing benefit.
Initially a marijuana joint might cause hours of 'calm' but in the addict a half hour is a good success.  The alcoholic will get maybe 10 minutes of benefit from a shot when they're in withdrawal. Indeed the 'anxiety' and 'irritability 'seen in addiction is 'withdrawal.'
If you are using a substance that has caused the addiction to treat the anxiey which is the way the 'withdrawal' is experienced, then it's like pour gasoline on a fire.  There's that briefest moment when the fire is 'doused' but after that the fire is clearly a whole lot worse.
As early as the 30's alcohol withdrawal was called 'restless, irritable, and discontent", "the RID's".  Marijuana has been called 'marijuana maintenance' for those who mixed alcohol and marijuana or switched from alcohol to marijuana. Regardless the marijuana 'withdrawal' is experienced as the 'RID's" as well and lasts weeks if not months.
Drug seeking addicts will always tell me that they felt anxious off marijuana, alcohol or heroin in fact.  The truth is that those who develop addiction had an underlying 'anxiety disorder' and were 'self medicating'.  Normal people don't 'self medicate' and control the use of substances reasonably because they don't have the same underlying anxiety disorder.
Once an addiction is established it takes at least a year, some say 5 years, to be over the addiction. Seasons, 4 of them, seem to be associated with differing 'trigger's' for relapse.  So 'recovery' is not considered to be 'weeks' or 'months' but rather 'years'.
So what to do when a marijuana smoker is 'bullying' and even 'threatening' you and definitely angry if their agenda is thwarted in any way, when they see the doctor and ask for his support in getting them the 'license' to smoke marijuana.  It's said on the 'street' that 'good' doctors 'sign' and 'bad' doctors don't.
The government and it's regulatory bodies are all giving mixed messages but mostly their song is 'opinion poll' and 'cover your ass'.  As usual, clinicians, like soldiers are on their own, damned if they do and damned if they don't but certain to be judged by "monday morning' quarter backs with sometimes years to mull over a decision the clinician must make in the 'real world 'of 'here and now."
I'm in the middle. I've definitely supported 'medical marijuana' for some patients and am wholly behind 'decriminalization' of drugs, drug court and yet I draw the line at full 'legalization' because it will increase the risk to those who are vulnerable and society at large will definitely have more traffic accidents and work accidents and psychiatric problems.
I'd like to be 'black or white' in this grey area.  It's the same with benzodiazepine (valium type drug) prescriptions where patients who are addicted to marijauna, or alcohol or heroin say that the 'benzos' take the edge off.
My oath is 'do no harm' .  In the short run there are 'benefits but in the long run I'm probably at risk of compounding the patients problems.
Each case I think is unique but the politics treat the world as a mass and certainly the marijuana promoters are 'recruiter's and have a 'conflict of interest'. I've none but it's a challenge and I thought it worth mentioning.
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